PTGS2 and psychiatric disorder: Randomized controlled trials of COX-2 inhibitors as adjunctive therapies in children with treatment-resistant psychiatric disorders with a potential immune-mediated component may be warranted, beyond the single study of celecoxib in ASD noted by Sethi et al. Reassuring safety data exist for both celecoxib and non-selective NSAIDs, derived from studies of children with juvenile idiopathic arthritis (51) and familial adenomatous polyposis (52).