Specifically, VRK2, NT5C2, INO80E, YPEL3, and MAPK3 are the common candidate genes of SCZ and BMI; NT5C2, FES, and FURIN are the candidate genes for both SCZ and CAD; ARL6IP4, OGFOD2, PITPNM2, CDK2AP1, C12orf65, ABCB9, SETD8, MPHOSPH9, SREBF1, TOM1L2, and GATAD2A are associated with the comorbidity of SCZ and T2D; SLC39A8, AMBRA1, C12orf65, and SETD8 are associated with the comorbidity of SCZ and HDL; GATAD2A and TM6SF2 are the common candidate genes of SCZ, TC, and TG. This evidence concerns the gene SREBF1 and type 2 diabetes mellitus.