Emerging evidences suggested that HMGB1/TLR4/NF-κB signaling was firmly associated with the activation of HSCs as well as the synthesis of ECM, and inhibition of HMGB1 could significantly reduce inflammatory response and ameliorate liver fibrosis (Luedde and Schwabe, 2011; Li et al., 2014). Here, HMGB1 is linked to Hepatic fibrosis.