In our previous work, JPYF II was shown to increase catalase (CAT) and glutathione peroxidase (GSH-Px) activity and reduce malondialdehyde (MDA) production in the lung tissues of a mouse model of LPS and CS-induced COPD, establishing the antioxidative properties of JPYF II (Fan et al., 2018). This evidence concerns the gene CAT and chronic obstructive pulmonary disease.