Our recent study showed that L-4F treatment inhibited tumor progression significantly is relevant to reduce the secretion of IL-17A, IL-6, GM-CSF and IL-1β in the tumor tissue, and suppressed tumor-associated macrophage (TAM) differentiation and infiltration of the tumor tissue, and L-4F inhibited M2 macrophage differentiation, it was relate to the inhibition of STAT3 and MAPK pathways (Peng et al., 2017). This evidence concerns the gene CSF2 and neoplasm.