Through the up-regulation of one more miRNA, i.e., miR-124 targeting the IL-6 receptor gene (Xiao et al., 2015), SFN counteracted CIS-activation of IL-6/STAT3 pathway, which seems to be involved in CIS-induced expansion of CSC cells (Wang et al., 2016). This evidence concerns the gene STAT3 and in situ carcinoma.