ALB and Hyperglycemia: In this study, the renal protection of CR during hyperglycemia was successfully demonstrated by the suppression of NAG (P < 0.05) (Figure 4A) and BUN (P < 0.05) (Figure 4B) in the urine, ALB in the serum (P < 0.01) (Figure 4C), and PKA (P < 0.05) (Figure 4D) and 6-keto-PGF1α (P < 0.05) (Figure 4E) in the kidneys of db/db mice after 8-week administration.