SIRT1 and metabolic disease: Sirtuin 1 (SIRT1) regulates protein deacetylation, participates in protein transcription and translation, regulates cell proliferation, oxidative stress, and metabolism, and plays an important role in metabolic diseases, tumors, and cardiac function (Consiglio et al., 2014; Cui et al., 2016; Qin et al., 2016).