PI3K/Akt has been demonstrated to regulate a wide array of biological function in the hippocampus, such as anti-inflammation, anti-apoptosis, and neuroprotection, which may affect NMDA receptors and downstream signaling through TrKβ and BDNF to improve cognitive deficits (Mizuno et al., 2003; Li et al., 2015; Srivastava et al., 2018). Here, BDNF is linked to Cognitive impairment.