PLGA nanoparticles (NP), loaded with curcumin (cur-PLGA-NP) elevated the HIF-1 and NF-κB subunits (HIF-1α and nuclear p65 (Rel A) expression in breast and lung cancer cells at the hypoxic microenvironment (Khan et al., 2018). This evidence concerns the gene HIF1A and lung carcinoma.