ADCYAP1R1 and Anxiety: In our work related to stress- and pain-responding, only BNST and CeA infusions with PACAP altered anxiety- or pain-related behaviors (Hammack et al., 2010; Missig et al., 2014, 2017; Roman et al., 2014); parallel studies with VIP infusions had no apparent effects suggesting PAC1 receptor signaling in these behaviors.