OPRM1 and Alzheimer disease: Since DADLE may bind to MOR and MOR may have a different role in certain neural functions (Lutz and Kieffer, 2013; Xia, 2015; Shrivastava et al., 2017; Wang et al., 2018) and since non-neuronal cells may react to AD stress in a different way, it is important to adopt more specific methodologies in neuron-like cells to yield more reliable conclusions in terms of the role of DOR in the pathology of AD.