Having revealed a role for eEF1A in PI3K/AKT/mTOR mechanism in several cellular models (Amiri et al., 2006; Khwanraj et al., 2016), we sought to examine whether the eft-3 and eft-4 mediate neuroprotection through the cell survival signaling, PI3K/AKT/mTOR, in 6-OHDA-induced C. elegans PD model. This evidence concerns the gene AKT1 and Parkinson disease.