Furthermore, the promotion effects of anti-miR-506-3p or HMGA2 on the protein levels of PCNA and MMP9 also confirmed that miR-506-3p inhibition or HMGA2 overexpression could reverse the inhibition function of circ_100565 silencing on proliferation and metastasis in NSCLC cells (Fig. 6h, i). The gene discussed is HMGA2; the disease is non-small cell lung carcinoma.