In the Cox multivariate survival analysis adjusted for age, gender, Dukes stage, the tumor grade, and tumor location, a moderate TLR4 immunoreactivity (HR 0.66, 95% CI 0.49–0.89, p = 0.007) compared with a strong TLR4 tumor expression served as an independent prognostic factor (Table 4). The gene discussed is TLR4; the disease is neoplasm.