Tumor cells compete with T cells for nutrients in the TME due to their similar metabolic processes, resulting in compromised T-cell receptor (TCR) signaling and dampened production of cytokines such as interferon-γ (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-α (TNF-α) [21–23]. The gene discussed is IL2; the disease is neoplasm.