Triple combination of the biomarkers (TERT@miR-122@AFP panel) showed the highest diagnostic performance in differentiating HCC from other forms of chronic liver diseases (HCC from LC, AUC = 0.88; HCC from CHB, AUC = 0.98; HCC from non-HCC or CHB + LC, AUC = 0.94) (Fig. 4). This evidence concerns the gene TERT and hepatocellular carcinoma.