Regarding periodontitis, there is an interplay between microbial species within subgingival biofilms and the adjacent periodontal tissues6, which elicit the innate immunity by releasing chemokines, such as the CXCL-8/IL-8 into the gingival crevicular fluid (GCF)31 necessary to recruiting neutrophils. The gene discussed is CXCL8; the disease is periodontitis.