PDE3B and metabolic syndrome: On the T2DMwell-DL-P vs. H comparison, which evaluated the stimulus of T2DM with good glycemic control and the presence of dyslipidemia and periodontitis, the RT-qPCR results from circulating lymphocytes and monocytes validated that the BPTF (bromodomain PHD finger transcription factor) and PDE3B (phosphodiesterase 3B) genes were upregulated in H, and the FN1 (Fibronectin 1) gene was downregulated in the same group (Fig. 5B).