Senescent T cells (referred to as senescence-associated T cells; SA-T cells), defined as CD4+ CD44high CD62Llow PD-1+ CD153+ cells, accumulate in visceral adipose tissues (VAT) in obese individuals11 and produce proinflammatory cytokines, causing chronic inflammation, metabolic disorders, and cardiovascular diseases12,13. This evidence concerns the gene TNFSF8 and metabolic disease.