MKI67 and neoplasm: Proliferative activity marker Ki-67 reveals the rate of division of cellular nuclear materials28 (that is possibly discordant with the mitotic index29), while lactate enhances the survival advantage of tumour cells reflecting invasion capability.6 The negative correlation against LDH-A was likely the result of feedback inhibition30 and depletion of pyruvate and nicotinamide adenine dinucleotide hydrogen (NADH)31 in higher grade tumour.