Postmortem studies have reported decreases in the NMDAR subunits NR2A and NR2B, the metabotropic glutamatergic receptor 2/3, mTOR and its downstream molecule eIF4B, phospho-eIF4B, and p70S6K in the prefrontal cortex of MDD patients9,10,29. Here, GRIN2A is linked to major depressive disorder.