GDF15 and infection: When CLP-induced neutrophil recruitment was almost completely eliminated by an anti–GR1-depleting antibody (Fig. 4F), mice died substantially faster than WT mice that had been treated with an isotype control antibody and, importantly, no differences in survival between genotypes were observed, supporting the hypothesis that increased neutrophil recruitment to the site of infection in Gdf15−/− mice accounts for their survival advantage in CLP.