PHLDA2 and Beckwith-Wiedemann syndrome: In mice, maternal inheritance of a Phlda2 deletion resulted in placentomegaly (Frank et al., 2002; Salas et al., 2004), which suggests that the dysregulation of Phlda2 expression caused by disrupted imprinting of the IC2 cluster can lead to adverse placental phenotypes, one of the hallmark BWS symptoms.