Five to 10% of SRS patients are reported to have duplication (Monk et al., 2000; 2002; Eggermann et al., 2012b) or mUPD on chromosome 7 (Yuan et al., 2016), where growth factor receptor-bound protein 10 [GRB10; also known as maternally expressed gene 1 (MEG1)] resides. The gene discussed is GRB10; the disease is Silver-Russell syndrome.