More surprising is the observation that the deletion of α3β1 does not cause the egress of HB SCs under normal homeostatic conditions, even though α3β1-depleted, K15-positive keratinocytes are found in the upper parts of HF and in IFE of K14 Itga3 KO mice (Sachs et al, 2012). Here, KRT14 is linked to hydrops fetalis.