Although CCN2 could be detected in all K19 Itga3 WT tumors analyzed, a small number of CCN2-positive cells (the mean CCN2-positive surface is 0.27% of total tumor area) together with their non-HB origin indicates that CCN2 does not play a major role in the late stages of tumor growth (Fig S4C). This evidence concerns the gene CCN2 and neoplasm.