Furthermore, MSCC WT keratinocytes showed an increased expression of CCN2 when the conditions that occur during DMBA/TPA treatment were mimicked by application of either TPA or IL-6, the cytokine up-regulated during DMBA/TPA tumorigenesis and crucial for tumor formation (Ancrile et al, 2007) (Fig 7A). This evidence concerns the gene IL6 and neoplasm.