Although both K19 Itga3 KO and WT mice developed numerous tumors by the end of the treatment (K19 Itga3 KO 33.8 and WT 49.1 tumors on average), there was a marked 30% decrease in tumor formation and a 15% decrease in the average tumor size upon the deletion of Itga3 in HB SCs (Figs 4A and B and S3A). Here, ITGA3 is linked to neoplasm.