CRB1 and Leber congenital amaurosis: However, some genes associated with congenital stable, or very early-onset progressive, visual impairment were among the top 10 genes in the pediatric cohort, but not in the overall cohort, as follows: CACNA1F, associated with incomplete congenital stationary night blindness; CNGA3 and CNGB3, associated with achromatopsia; and RPE65 and CRB1, associated with Leber congenital amaurosis or early-onset severe retinal dystrophy.