SHBG and rheumatoid arthritis: There was also a significant causal association between SHBG levels and OA (effect = 1.006; 95% CI, 1.000 to 1.011; P = 0.032) and RA (effect = 1.006; 95% CI, 1.001 to 1.011; P = 0.025) in female patients (Supplementary Table 10).