Other disease settings could for example be T1D with its restriction to both HLA-DR and -DQ loci [55] and the numerous autoantigens involved, like GAD and 60 kDa heat shock protein (HSP60) [56, 57] as well as coeliac disease with the HLA-DQ2 and -DQ8-restricted gluten-derived peptides [58, 59]. Here, GAD1 is linked to celiac disease.