NPPB and Sepsis: After being treated with rSj-Cys, the MPO activity in the myocardial homogenate and cTnI, Mb, NT-proBNP in sera were significantly reduced in mice with sepsis compared with CLP mice without treatment (ANOVA: F(3, 23) =32.10, P < 0.0001; F(3, 23) = 61.36, P < 0.0001; F(3, 23) = 10.42, P < 0.0002; and F(3, 23) = s42.79, P < 0.0001, respectively) (Fig. 2b), while cTnI, NT-proBNP, Mb and MPO remained at low levels in mice with sham surgery and there was no significant difference between sham surgery groups and sham with treatment of rSj-Cys groups.