To determine if MyD88 is involved in the therapeutic effect of rSj-Cys on sepsis-induced inflammation and damage of cardiomyocytes, we detected the expression of MyD88 in heart tissue of mice with CLP-induced sepsis treated with rSj-Cys in vivo, and in LPS-stimulated H9C2 cells co-incubated with rSj-Cys in vitro. Here, MYD88 is linked to Sepsis.