Treatment with rSj-Cys significantly reduced the production of TNF-α and IL-6 in CLP-induced sepsis mice, compared with CLP mice without treatment (ANOVA: F(3, 23) = 18.39, P < 0.0001 and F(3, 23) = 361.3, P < 0.0001, respectively) (Fig. 3a). The gene discussed is TNF; the disease is Sepsis.