The aim of the study was to evaluate of PARP1, PARP2, PARP3 and TRPM2 gene expression at mRNA level in the cells of the hematopoietic system of the bone marrow in patients with acute myeloid leukemia, bone marrow from healthy patients, peripheral blood of healthy individuals, and hematopoietic stem cells from the peripheral blood after mobilization. Here, TRPM2 is linked to acute myeloid leukemia.