Adverse effects of L-asparaginase include hypersensitivity reactions, including urticaria and anaphylaxis, thrombosis, hepatotoxicity, hypertriglyceridemia, hypoalbuminemia, intracranial hemorrhage, encephalopathy, myelosuppression, hyperglycemia, pancreatitis, and rarely diabetic ketoacidosis (DKA) [7–9]. Here, ASPG is linked to Hyperglycemia.