Furthermore, the immunogenic effect of chemotherapy in mouse and human prostate tumors, requires the removal of an immunosuppressive B cell subtype, plasmocytes that express IgA, interleukin (IL)-10 and programmed death ligand 1 (PD-L1) - the appearance of which depends on TGFβ receptor signalling - that induce CD8+ T cell exhaustion and suppress anti-tumor CTL responses [36]. This evidence concerns the gene CD274 and neoplasm.