However, Schwartzentruber et, al. in 2011, reported encouraging results from a randomized phase III trial involving patients with stage IV or locally advanced stage III cutaneous melanoma) in which the group treated with the gp100 (210M) peptide in Montanide ISA-51 adjuvant plus IL-2 demonstrated a statistically significant improvement in overall clinical response (16% vs. 6%, P = 0.03), longer progression-free survival (2.2 months vs. 1.6 months, P = 0.008) and improved median overall survival (OS = 17.8 vs. 11.1 months; P = 0.06) compared with the IL-2 group [125]. Here, IL2 is linked to cutaneous melanoma.