ACE2 and COVID-19: COVID-19-induced reduction of ACE2 (angiotensin-converting enzyme 2), which regulates inflammation and is already present in lower levels in the elderly, has been proposed as a possible mechanism leading to higher disease severity.16 ACE2 is also a component of Leydig cells within the male testes, leading to a potential site of infection and viral safe harbor, which may contribute to the higher percentage of male patients with COVID-19 as compared with females.17 However, further investigation is necessary to elucidate how age and sex influence clinical presentation.