OD is an expected element of coronavirus pathophysiology.6 Expression of the SARS-CoV-2 host cell surface receptor, angiotensin-converting enzyme 2 (ACE2), is highly expressed in nasal mucosa, in particular the ciliated epithelium and goblet cells.23,24 Moreover, viral replication appears to be greatest in the nasal cavity, as evidenced by the highest viral titers shed from the nose.25 Finally, coronaviruses have been shown to be highly neurotropic in animal models where olfactory neurons have been shown to be directly permissible to infection.26, -28. This evidence concerns the gene ACE2 and infection.