INS and diabetes mellitus: Diabetes mellitus has been characterized by a decrease in glycogen storage due to defectsin insulin secretions, which comes as a result of selective destruction of β-cells of the pancreas.8 Malini et al37 reported that glycogen is the primary intracellular storage form of glucose and itslevels in various tissues are a direct reflection of insulin concentration, since insulinpromotes intracellular glycogenesis by stimulating glycogen synthase and inhibiting glycogenphosphorylase.