The interaction with several proteins involved in gene expression (Table 1), the role of Y RNA in DNA replication, the putative role of some of them as potential tumor suppressors, the possibility to hit distant targets through EV or other carriers (such as free RNP in plasma), and their possible role in establishing a tumor-friendly microenvironment, all point to their possible involvement in tumorigenesis. This evidence concerns the gene RNPC3 and neoplasm.