RNPC3 and neoplasm: In this work, the authors analyzed the ncRNA content inside cells, in EV (including micro-vesicles and exosomes) and as free RNP; as for the cell type, the choice was for low-passage patient-derived tumorigenic glioblastoma multiforme (GBM) cells, the most therapy-resistant stem-like cell population and considered the core cell type within the tumor, while the controls were obtained through the transcriptome analysis of primary human and mouse cells of the brain microenvironment, including neurons, astrocytes, endothelial cells, and microglia.