RO60 and melanoma: As for melanoma and non-melanoma skin cancer (NMSC) in these patients, it is not yet clear if RO60 is directly involved, or if the auto-antibodies cross-react with other targets, possibly being part of the same RNP complexes, or even if inflammation per se has a direct, stimulatory role in cell growth, especially for NMSC (see [96] and references therein).