Thus, polymorphisms in the A Disintegrin and Metalloprotease 33-ADAM 33 (20p13) and OrmDL3 (17q21) genes increase susceptibility to wheezing in infancy and possibly later-life Chronic Obstructive Pulmonary Disease—COPD, but not necessarily asthma. This evidence concerns the gene ORMDL3 and chronic obstructive pulmonary disease.