We previously demonstrated that the intratumoral vaccination with a recombinant vaccinia virus encoding for ErbB2/Neu (rV-neuT) induced a strong antitumor response and antitumoral activity in mammary and salivary gland tumors overexpressing ErbB2/Neu in BALB-neuT mice [2,18]. The gene discussed is ERBB2; the disease is tumor of salivary gland.