NFE2L2 and cancer: It was noted previously that Nrf2 regulates the expression of metabolic enzymes such as G6PD, PGD, and TKT, as well as of the enzymes involved in NADPH synthesis; with regard to cancer cells, the overactivation of Nrf2 implies the induction of these enzymes, ensuring the availability of energy for cell division and growth and contributing to metabolic reprogramming for cell proliferation [79].