The authors hypothesized that patients characterized by higher ACE1 activity (i.e., D/D-genotype) in conjunction with reduced ACE2 activity (i.e., GG-females or hemizygous G-males) could account for increased susceptibility to hypertension mainly in association with classical cardiovascular risk factors such as old age, dyslipidemia, and diabetes [97]. The gene discussed is ACE; the disease is Hypertension.