Most likely, it is plausible that a combination of the mechanisms described above might influence the multistep pathogenesis and the age/sex-gaps of such a complex infection and progression, considering also that ACE2 (locus Xp22.2) and Ang-II receptor type 2 gene (AGTR2, alias AT2, locus Xq23) are both located on the X-chromosome. The gene discussed is ACE2; the disease is infection.