Moreover, a high ACE2/ACE1 ratio protects against endothelial dysfunctions and vascular pathologies, exogenous ACE2 activation promotes antithrombotic activity, and the known antithrombotic properties of captopril (ACE inhibitor) and losartan (AT1-receptor blocker) are attenuated by a selective Ang 1–7 receptor antagonist [53,54]. Here, ACE2 is linked to endothelial dysfunction.