TNF-α was significantly expressed in MDR-PA-infected RPE cells at 6 h (13.03-fold vs. 4.41-fold; p = 0.02) and 12 h (7.15-fold vs., 1.55-fold; p = 0.02) post-infection, while activation of IFN- γ was observed up to 12 h (>3-fold; p = 0.01). The gene discussed is TNF; the disease is infection.