Moreover, parenchymal PMN–MDSC in human renal cell cancer, have a positive correlation with IL1-β, CXCL8, CXCL5 and CCL3 and CXCR2 blockade reduced tumor weight with enhanced CD4+ and CD8+ T-cell infiltration in renal cell carcinoma-bearing mice [134]. The gene discussed is CD8A; the disease is neoplasm.