In human hepatocellular carcinoma (HCC) tissues and HCC-bearing mice, PD–L1 and PD-1 were expressed in peritumoral neutrophils and T lymphocytes, respectively, and PD–L1+ neutrophils from patients with HCC effectively suppressed the proliferation and activation of T cells by utilizing the PD-1/PD–L1 interactions [122]. This evidence concerns the gene CD274 and hepatocellular carcinoma.