TNF and neoplasm: Molecular events including secretion of toxic radicals (e.g., reactive nitrogen species and reactive oxygen species), production of cytokines that enhance tumor cell growth (including TNF-α, IL-6, and IL-10), upregulation of TGF-β (which increases tumor cell tissue invasion), and increase in the expression of IL-17 (which upregulates angiogenesis) [64,65,66] are some of the means by which inflammatory conditions are linked directly to tumorigenic responses.