icmt mRNA in various human chronic inflammatory diseases was revealed to be elevated in patient groups with inflammatory-dilated cardiomyopathy (IC), rheumatoid arthritis (RA), Crohn disease (CD), ulcerative colitis (UC), and inflammatory bowel disease (IBD) in ileum (I) and colon (C) compared to healthy groups, with an up to three-fold-increase observed in inflammatory bowel diseases (Figure S3). This evidence concerns the gene ICMT and Crohn disease.