Finally, since functional role of MyD88 or TRIF in inflammatory responses is cell-type specific in DSS-induced colitis and colorectal cancer models [82,83], therefore, we will also dissect functional involvement of ICMT/Ras pathway with different cells (e.g., intestinal epithelial cells) with knockout conditions of MyD88 and TRIF in the following projects. The gene discussed is MYD88; the disease is colitis.