Under ICMT-/- conditions in RAW264.7 cells, most Ras family members, including K-RAS, H-RAS, N-RAS, RANPBP1, RHOC, and RASA1, showed 50% or greater reductions in expression during LPS stimulation, implying that Ras and its related molecules are important in modulating inflammatory responses in immune and cancer cells mediated by PRRs or other stimuli including cytokines. The gene discussed is HRAS; the disease is cancer.