ICMT and colitis: To prepare mouse models of inflammation, we used several well-known pathological conditions including atopic dermatitis triggered by 2,4-dinitrofluorobenzene (DNFB), colitis induced by DSS, gastritis generated by HCl/EtOH, and hepatitis induced by LPS/D-galactosamine (D-GalN), as reported previously [40,43,45,46] and measured levels of icmt mRNA and ICMT protein in these disease models.