All patients underwent on-tumor-site radiotherapy or radio-chemotherapy with a prescribed dose of 70 Gy (2 Gy per fraction) in Simultaneous Integrated Boost, with, in case of radio-sensitization, 3 courses of cisplatin 100 mg/m2 or Epithelial Growth Factor Receptor (EGFR)-targeted therapy, such as cetuximab, weekly (400 mg/m2 loading dose 8 days prior to radiotherapy, followed by a course of 250 mg/m2 weekly, concurrent with radiotherapy). This evidence concerns the gene EGFR and neoplasm.