Here, even if there lies the possibility of SOD1 sequestering either protein, RNA, or both, by chance, further research should be conducted in identifying the consistencies amongst SOD1 aggregates, even if less commonly found in sALS patients; more importantly, this would confirm whether TDP-43, if not other RBPs, is a key point of convergence across ALS phenotypes, especially if specific treatment responses prove highly varying. Here, TARDBP is linked to amyotrophic lateral sclerosis.