Finally, regarding our discussions in understanding the close interrelationship between SOD1 and RBPs TDP-43 and FUS, this re-examined perspective of the non-RBP may help researchers better understand the seemingly causative heterogeneity exhibited in the common mutant SOD1 fALS patients and those non-mutant SOD1 ALS patients. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.