Apart from TDP-43 and FUS, more than 40 additional RNA-binding proteins have been characterized from the human proteome that contain predicted prion-like domains [124], with multiple being associated with ALS including HNRNP A2/B1, HNRNP A1, EWSR1, TAF15, ATXN2, MATR3, and TIA1 [5,125]. The gene discussed is EWSR1; the disease is amyotrophic lateral sclerosis.