Whether dysfunction proves to be due to SOD1 triggering RBP aggregates of TDP-43 and/or FUS or vice versa, or with miRNA dysfunction therefore having led to such, or both, there is a deep, under-researched interrelationship between these proteins that may shed even greater light onto the pathogenesis of ALS. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.