MATR3 and amyotrophic lateral sclerosis: Interestingly, the similarities between FUS interactions with Drosha and neuronal pri-miRNAs also extend to other critical RBP genes including FUS, TAF15, ATXN2, MATR3, hnRNPA2/B, EWSR1, hnRNPA1, and TIA1, which further supports the almost universal relevance of RBPs, miRNAs, and RNA metabolic dysfunction across both sporadic and familial forms of ALS, despite observed heterogeneity [26,80].