In ALS, more than 50 genes [4] have been linked to pathogenesis, with the most significant being superoxide dismutase-1 (SOD1), fused in sarcoma/translocated in liposarcoma (FUS/TLS), and transactive response DNA-binding protein (TDP-43), all of which share several properties related to RNA regulation, with the latter two true RNA-binding proteins themselves (RBPs). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.