SOD1 and amyotrophic lateral sclerosis: In relation to SOD1 misfolding in sALS, where SOD1 mutation is excluded, recent studies suggest that non-native conformers of SOD1 may also participate in a unified pathological mechanism that is shared amongst different forms of the disease [144], which further suggests the lack of a central, homogenous cause behind more parochial approaches to ALS pathogenesis, especially when foregoing the significance of protein and miRNA dysfunction.