Considering this, one should always remain wary of the likelihood of ALS being attributed to several etiologies, and thus a value exists in understanding this final “common ground” before the more downstream pathogenic effects that are known to characterize the disease, particularly as this appears to be the tight interrelationship between miRNAs and RNA-modifying proteins, especially RBPs TDP-43 and FUS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.