TARDBP and amyotrophic lateral sclerosis: However, it must also be noted that the examined literature for each protein in relation to miRNA dysregulation has often led to inconclusive evidence about specific miRNAs in ALS, instead depicting a wide spectrum of certain affected miRNAs, despite no evident connection between them; notably, research has been specific to mouse models or fALS patients depicting exclusive genetic mutation, whether it be in TARDBP, FUS, or SOD1.