SOD1 and amyotrophic lateral sclerosis: Interestingly, another recent study supports this notion, noting that although no variation was found in extracellular vesicles between ALS patients and the controls, both MVs and EXOs were found to have increased in size, with both methods significantly enriched in toxic TDP-43, phospho-TDP-43, FUS, and SOD1 when compared to the controls [145].