SOD1 and amyotrophic lateral sclerosis: This is supported by the presence of TDP-43 inclusions in 97% of ALS cases [6], which may contain other proteins (like those involved in stress response), although only a minority of sALS cases show either FUS- or SOD1-positive inclusion bodies [6,7,8,9], with the former eliciting no proven overlap with TDP-43 aggregates [10,11].