TARDBP and amyotrophic lateral sclerosis: It is also noteworthy to consider that, like TDP-43 and FUS, SOD1 also displays these prion-like features of aggregation and misfolding, but also in seeding, thus prompting our suggestion of investigating non-RBP SOD1 with a similar mindset to our approach to dysfunctional RBPs in ALS pathogenesis.