In patients with allergic rhinitis to HDM, we observed a moderate positive correlation between baseline values of TNF-α and IL-8 (r = 0.327, p = 0.01), IL-6 and IL-8 (r = 0.437, p = 0.001), weak negative correlation between VCAM-1 and IL-8 (r = −0.290, p = 0.03) and a weak positive one between TNF-α and IL-6 (r = 0.260, p = 0.04). This evidence concerns the gene IL6 and allergic rhinitis.