The findings of their study are supported by a study conducted by Hochedez et al. [19] on 102 patients in Martinique from 2010 to 2013, where a bilirubin test >49 μmol/L, creatinine >153 μmol/L, urea >9.3 mmol/L, creatinine phosphokinase >443 U/L, lymphocytes <0.49 × 109 cells/L, C- reactive protein >282 mg/L, hemoglobin <12.2 g/dL, platelets <92 × 109 cells, and prothrombin time <68% are significantly associated with severe leptospirosis patients. The gene discussed is F2; the disease is leptospirosis.