In patients with neurodegenerative disorders, such as AD, PD, ALS, and ALS/PDC [12], the characteristic proteins associated with each disease (phosphorylated tau, phosphorylated α-synuclein, and phosphorylated TDP-43) are misfolded, which results in the formation of abnormal intracellular protein aggregates, leading to cellular dysfunction and, eventually, neuronal cell death. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.