Furthermore, Kii ALS/PDC is a multiple proteinopathy, presenting as a tauopathy similar to Alzheimer’s disease (AD), α-synucleinopathy similar to Parkinson’s disease (PD), and TAR DNA-binding protein 43 (TDP-43) proteinopathy similar to ALS [5,6]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.