BAG3 and amyotrophic lateral sclerosis: In our data, gene expression levels of Hsp family members DNAJB1 (HSP40 member), HSPD1 (HSP60 member), HSPA6 (HSP70 member), and BAG3 were all significantly decreased in ALS/PDC brains, a finding that was further confirmed by qRT-PCR analysis (Figure 2C).