Moreover, HLA-DRB5-DRB1 and HLA-A*03:01/HLA-B*07:02/HLA-DRB1*15:01/HLA-DQA1*01:02/HLA-DQB1*06:02 haplotypes are reportedly risk factors for AD. This evidence concerns the gene HLA-DRB1 and Alzheimer disease.