As a strong agonist of the RXRs, the retinoid bexarotene synthetic agonist [120], which the U.S. FDA approved for the treatment of cutaneous T-cell lymphoma [121], was described to improve cognitive deficits in AD mouse models [122,123,124,125,126,127] mainly by inducing the transcription and lipidation of APOE and reducing microglial expression of pro-inflammatory genes among others [128,129]. This evidence concerns the gene APOE and Cognitive impairment.