Treatment of an adenocarcinoma colon cancer cell line, COGA-1A, with 10 nM 1,25-dihydroxyvitamin D (1,25-OHD) inhibited the upregulation of COX-2 mediated by TNF-α by 37% after 12 h [16]. The gene discussed is PTGS2; the disease is malignant colon neoplasm.