In an AOM/DSS-colitis mice study, vitamin D3 supplementation (15, 30, and 60 IU·g−1·w−1 3x/week) showed significant preventive effects in high doses, decreased the number of neoplasms by 33–63%, and increased E-cadherin expression, suggesting inhibition of colonic carcinogenesis progression [69]. This evidence concerns the gene CDH1 and infectious otitis media.