For instance, obese patients with melanoma show an increase in PD-1 expression within the TME, particularly in patients aged > 60, with increases in the expression of other markers of exhaustion as well: LAG-3, Tim-3, T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), and the transcription factors T-Box Transcription Factor 21 (TBX21) and Eomesodermin (EOMES) [54]. This evidence concerns the gene TBX21 and melanoma.